Cymbalta Withdrawal Stack

Revision 2

The Cymbalta Withdrawal stack is our most popular stack. It was built to support and help your brain and body through the massive impact these medications have when discontinuing  them. This stack can be started at the same time you start your tapering process, or after stopping.

Supplementing dosage can be increased or decreased at anytime as you see fit. These are not a one size fit all!

Cymbalta Stack:

Black Seed Oil/Powder

  • Dosage/Schedule

Recommended Dosage: Start at one teaspoon every morning after a small meal. If needed, move to one in the morning and one at night after small meals.

Fish Oil

  • Dosage/Schedule

Take every morning

Recommended Dosage: 1000 mg DHA and 500 mg EPA (1500 mg total)

N-acetyl-cystein (NAC)

  • Dosage/Schedule

Every day to ever other day. Can be taken in the mornings or at night, personal preference.

Recommended Dosage: Start at 500-600 mg

Take as needed:

Ashwagandha Root – Anxiety

  • Dosage/Schedule

Recommended Dosage (Ashwagandha Root): 600 mg to 2 grams starting dosage, with food. Increase as necessary.

Recommended Dosage (KSM-66): 3-500 mg per day and up to 6,000 mg split into multiple doses as the optimal limit.

Melatonin – Sleep

  • Dosage/Schedule

Recommended Dosage: 0.1 – 0.5 mg per day, taken one hour before bed. Can be taken while still tapering off anti depressants.

5-HTP – Sleep & ‘Brain Zaps’

  • Dosage/Schedule

** Caution while taking when still on Anti-depressants **

Recommended Dosage: 3 – 500 mg per day. Taken 1 hour before bed or as needed for brain-zaps.

  • Black Seed Oil
  • Fish Oil
  • N-acetyl-cystein (NAC)

Black seed oil is a strong antioxidant and anti-inflammatory compound. It’s included in this stack is there is evidence it acts as a neuroprotective agent, combats anxiety and depression as well as reducing cancer risk. The main psychoactive molecule is “thymoquinone”. This supplement is the most essential in this stacks as it greatly reduces the withdrawal effects of anti-depressants.

Fish oil is included here as it’s the most popular supplements. It contains a lot of omega-3 fatty acids (EPA and DHA), which help reduce inflammation in the body, which includes in the brain. Fish oil will help maintain memory and is a cognitive protecting agent. It has become one of the most well-studied health supplements on the market.

This is an antioxidant and prodrug for L-cysteine, which can increase levels of glutathione. It is well studied and shown to have a great impact on a variety of mental illnesses. This drug was chosen as it can greatly reduce depressive/obsessive thoughts which can be a huge side effect when discontinuing anti-depressants.

  • Ashwagandha
  • Melatonin
  • 5-HTP

Ashwagandha is an Ayurvedic herb that has been used for over 3000 years. It is mainly used to treat anxiety and stress, but can also improve cognitive abilities and has neuroprotective and cancer-reducing properties. This is added on an as-needed basis, but can be taken everyday as studies have shown there are no negative effects of doing so.

Melatonin is a hormone produced in our bodies during the “dark” cycle to aid in restful sleep and regulating an individuals circadian rhythms. Melatonin is included here as it’s a potent sleep aid when taken in smaller micro-doses and can assist with sleep issues during this time of irregular brain chemistry.

5-HTP is a precursor molecule for the brain chemical, serotonin. It is a potent serotonin enhancer and used for mood enhancement as well as sleep. Dosing needs to be done carefully as taking too much 5-HTP can lead to serotonin syndrome. This is included in the stack for sleep because serotonin converts into melatonin, which can be a potent sleep aid.


Through Plasticity we will overcome. Despite what we knew in the past, our brains are easily shaped and ever-changing. We strive to take advantage of this adaptability with supplements in order to overcome the withdrawal effects of antidepressants.

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