Cymbalta Withdrawal Stack

Revision 2

The Cymbalta Withdrawal stack is one of our most popular supplement stacks. It was built to support and help your brain and body through the massive impact these medications have when discontinuing them. Please read the dosage and schedule of each supplement as some of this stack should be used only after antidepressant discontinuation. Please see our taper guide here.

Supplementing dosage can be increased or decreased as you see fit.

Cymbalta Stack:

Black Seed Oil/Powder

  • Dosage/Schedule

Recommended Dosage: Start with one teaspoon every morning after a small meal. If needed, move to one teaspoon in the morning and a teaspoon at night. Take with food to prevent stomach discomfort.

Fish Oil

  • Dosage/Schedule

Take with 1-3 meals throughout the day

Recommended Dosage: 1000 mg DHA and 500 mg EPA (1500 mg total)

N-acetyl-cystein (NAC)

  • Dosage/Schedule

Every day to ever other day. Can be taken in the mornings or at night, personal preference.

Recommended Dosage: Start at 500-600 mg

Take as needed:

Ashwagandha Root – Anxiety

  • Dosage/Schedule

Recommended Dosage (Ashwagandha Root): 600 mg to two grams starting dosage, with food. Increase as necessary.

Recommended Dosage (KSM-66): 3-500 mg per day, can be split into multuple doses.

Melatonin – Sleep

  • Dosage/Schedule

Recommended Dosage: 0.1 – 0.5 mg per day, taken one hour before bed.

Can be taken while still tapering off antidepressants.

5-HTP – Sleep & ‘Brain Zaps’

  • Dosage/Schedule

** CAUTION risk of serotonin syndrome – do not take when on antidepressants **

Recommended Dosage: 3 – 500 mg per day. Taken 1 hour before bed or as needed for brain-zaps.

  • Black Seed Oil
  • Fish Oil
  • N-acetyl-cystein (NAC)

Black seed oil is a strong antioxidant and anti-inflammatory compound. It’s included in this stack is there is evidence it acts as a neuroprotective agent, combats anxiety and depression as well as reducing cancer risk. The main psychoactive molecule is “thymoquinone”. This supplement is the most essential in these stacks as it greatly reduces the withdrawal effects of anti-depressants.

Fish oil is included here as it’s the most popular supplements. It contains a lot of omega-3 fatty acids (EPA and DHA), which help reduce inflammation in the body, which includes in the brain. Fish oil will help maintain memory and is a cognitive protecting agent. It has become one of the most well-studied health supplements on the market.

This is an antioxidant and prodrug for L-cysteine, which can increase levels of glutathione. It is well studied and shown to have a great impact on a variety of mental illnesses. This drug was chosen as it can greatly reduce depressive/obsessive thoughts which can be a huge side effect when discontinuing anti-depressants.

  • Ashwagandha
  • Melatonin
  • 5-HTP

Ashwagandha is an Ayurvedic herb that has been used for over 3000 years. It is mainly used to treat anxiety and stress, but can also improve cognitive abilities and has neuroprotective and cancer-reducing properties. This is added on an as-needed basis, but can be taken everyday as studies have shown there are no negative effects of doing so.

Melatonin is a hormone produced in our bodies during the “dark” cycle to aid in restful sleep and regulating an individuals circadian rhythms. Melatonin is included here as it’s a potent sleep aid when taken in smaller micro-doses and can assist with sleep issues during this time of irregular brain chemistry.

5-HTP is a precursor molecule for the brain chemical, serotonin. It is a potent serotonin enhancer and used for mood enhancement as well as sleep. Dosing needs to be done carefully as taking too much 5-HTP can lead to serotonin syndrome. This is included in the stack for sleep because serotonin converts into melatonin, which can be a potent sleep aid.


The information on this website has not been evaluated by the FDA, and is not intended to diagnose, treat, prevent, or cure any disease.

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